Monday, December 7, 2009
Another Shot
Paper Dilemas, round 2
Journal Titles, Text for Pt.3
Recent Trends in Treating Musca ridere Infection In Humans
Paul Flight, Julia Pierce, and John Xi
In the twenty years since the initial outbreak of human infection by Musca ridere, popularly known as happy bugs, there has been very little variation in treatment. The accepted protocol, developed by Dr. Steven Kowalski five weeks after the first case was reported using the information in the infamous file that Lt. Col. Donal Molloy leaked to the public revealing the origins of the inexplicable illness, has remained in place because it is effective. The dual level treatment of repeated Dilipsolol injections and controlled application of electro magnetic interference (EMI) to the brain works to attack the larvae on both the biological and the technological level. It takes six days to complete the course of treatment, which must be administered in a hospital, largely due to the infected patient’s reliance on intravenous delivery for nutrition and liquids intake, and the patient has a 95% chance of being completely healed. However, the Kowalski protocol is not without its drawbacks: the CEMII (controlled electro magnetic interference immersion) machines are complicated and costly to maintain; the Dilipsolol causes physical discomfort and has a long list of fairly rare but serious side effects, (six percent of patients, mostly occurring in those below the age of five and above the age of sixty) including permanent blindness and heart complications; the treatment requires a long hospital stay which is often prohibitively expensive for those without health insurance; and it has a 5% mortality rate.
The last three years have seen increased public awareness of the problems posed by the Kowalski protocol, and a corresponding dramatic increase in the amount of funding and research being directed toward finding an improved treatment. This article seeks to examine the three new options that the authors find to be the most promising, discussing their function, merits, and hazards.
The Kowalski protocol is administered when the infection has reached its final stages and the Musca ridere larva is fully grown (fig.1) has taken residence in the hypothalamus portion of the brain. Several of the more serious complications that occur are the result of the larva poisoning or damaging the host’s brain as it dies. Finnish doctors Hinkka and Puustelli have been working on a preventative vaccine that attacks the parasites as they enter the bloodstream as they enter the bloodstream as eggs deposited by the bite of the mature fly (fig.2 &3). The drug, called Metpratenol, works by subtly changing the blood chemistry to be inhospitable to the eggs. As it currently stands it must be repeatedly injected, wearing off after 72 hours and has only proven
Figure 1. Larvae in final stage of growth.
50% effective on the very small sample population it has been tested on, but the concept is
strong. More research is being conducted into ways to make the minor blood chemistry adjustment permanent and a wider pool of clinical trail subjects is being gathered. The Finnish government is funding the research with aid from the drug company Biotie Therapies. The long term effects of changing the make-up of human blood are also a significant concern, and must be careful studied and considered at every step of the process. There has been public opposition to the research in Finland, with detractors making the claim that to change human blood on the molecular level is tampering with what it means to be human and should not be allowed.
Figure 2. Musca ridere eggs amongst red blood cells.
Here in the United States such research has been outlawed under the 2013 AntiGenetic Alteration Bill—ironically it is a bill created in reaction to the initial epidemic of Musca ridere infection that now hampers research into new ways of preventing it.
A second, and less controversial, promising avenue of research is being conducted in Canada by McGill University in Montreal. A group of doctors and scientists have created a stronger variation of the drug Dilipsolol. The new drug, called Trilipsolol only needs to be administered for three day to have the same effect, and the instances of reported muscular discomfort during treatment are greatly reduced.
Figure 3. Egg (enlargement)
However instances of seizures during clinical trials have kept the drug being approved for use and the team is conducting more research into the cause of the side effects.
The most startlingly simple line of research is being conducted here in the United States at Stanford University. Rather than focusing on how to fight the infection after it has already occurred, the Stanford team is focusing their funds and energies into ways to keep the infection from happening at all. Research into chemical insect repellants and devices that could electronically repel or kill the adult fly (fig.4) is underway, although so far very little progress has been made. Figure 4. Adult Mosca ridere.
Yup--messy when pasted in, but all there.
--The Wombat
Newspaper Clipping Text#2
Local mother arrested for child endangerment
By Will Jones
wjones@mercurynews.com
San Jose Police arrested Lisa Tyler, 41, Tuesday afternoon, responding to a report from neighbors who claimed to have witnessed the mistreatment of children in the Tyler house in the 500 block of Empire.
Upon their arrival police discovered the two children, ages 4 and 6, standing unresponsive in the front yard, clearly infected with the happy bug. Tyler was not at home and the children were taken into protective custody and rushed to Good Samaritan Hospital for treatment. When Tyler returned to the house several hours later she was immediately arrested and charged with children endangerment for having allowed the children to have become grinners and leaving them without supervision.
Tyler confessed to having infected her children purposefully, with the intention of making them more tractable.
“I just wanted them to stay still,” she said, “They never stay still and they never shut up. I just wanted a break.”
Tyler claims to have purchased the adult happy bugs from a dealer on St. James St. that the police closed down two months ago, and to have locked the children in their bedroom with the flies to infect them.
“It was one of the creepier things I’ve seen,” said arresting officer Charles Blake, “I’ve seen hundreds of grinners, but you just don’t expect to see it on tiny little kids—not since the initial outbreak. They just stood there like dolls. I don’t know how a mother could do that to her own children.”
Tyler, a nurse, did feed the children intravenously while they were infected and they are expected to make a full recovery.
Again, not pretty in this format, alas. But readable and that's something....
--The Wombat
Newspaper Clipping Text#1
Downtown San Jose
Drug Arrests Two men were arrested Wednesday afternoon when police officers armed with warrants raided a house in the200 block of Saint James Street. James Fraser, 23, and Ray Hunnicut, 27, both residents of the raided house, were charged with drug manufacturing and trafficking. Police seized 56 vials of viable happy bug larvae, six jam jars full of adult bugs, and one gene sequencer and incubator used to grow the insects. Fraser and Hunnicut are being held without bail for the hearing scheduled for Friday morning.
it looks much prettier in a neat, wee column, but I have no idea how how to make my blog do that....
--The Wombat
"Ahhhhhhh!"
That's the sound that could be heard coming from my room after I decided to try putting actual newsprint through my printer for authenticity's sake. It started ok, then promptly made a nasty crunching noise and died. I couldn't just pull the jammed out of the printer because newsprint is fairly delicate and it kept tearing off in wee bits instead of coming out in a sheet as normal paper is wont to do when one tugs on it. So I tore my room apart to find my toolbox that had the fancy screwdriver with the right head for the really weird screws that my printer is held together with and set to work taking the blasted thing apart. I did manage, and it even still worked when I put it back together again (a minor miracle really). The moral of the story is don't put newsprint through your cheap ink jet printer.
Newspapers smell funny.
Whoops.
I did the bad blogger thing. I've been keeping research notes, taking pictures, and all that good stuff but I just couldn't seem to make myself put it up online. Part of that it takes so damn long to upload anything to this site, and it seems like half of the time something goes wrong and I have to start over. Let's hope I didn't jinx myself there.....
Wednesday, November 18, 2009
Giant Purple Bug Worm Thing
So here's my 3D model thing. It is meant to be an enlargement (the actual thing being microscopic) of the Happy Bug Larva. My sketches were blue but I liked the purples better when I was looking around in the fabric store so I changed that. When I had sewn the whole thing up it looked like purple sausage links so it was back out to the store to get fabric paints to try to spice it up a little--now it's sort of cute.....oh well. I'm not sure bug larvae should be cute, but as it's meant to be a man-made bug maybe its designers also had art degrees or a weird sense of humor, or something like that. The whole thing took a lot longer than it should have--my sewing machine had a fit and had to be taken apart (I don't think it liked the last move very much) and then it had been a few years since I last sewed anything and I kept forgetting the simple stuff like which dials to adjust and the likes. Then stuffing a narrow tube in segments turned out to be extremely slow going if I didn't want to tear my seams. I did the body shaping by hand sewing/gathering with a fat needle and embroidery thread. I got the lights in ok, and sewed a battery pouch without too much trouble, and I managed not to get the electrical workings wet when I painted. There were originally meant to be model eggs and a fly too--a sort of life-cycle display, but I got sick and that slowed everything down this past week. I did make the eggs and the fly (and some red blood cells to for good measure) out of fimo clay but I fell asleep after I put them in the oven (my evil cold has been sapping my energy all week and I've just wanted to nap-- I never nap--it's weird). They turned black and the house smelled very bad. I got mad and threw them out--I should have taken pictures. But nothing caught fire so that's good, and I decided I'm not allowed to use the oven while under the influence of cold medication anymore......and that is the story of my purple bug larva, which looks pink in these pictures, alas, and is not quite as grand a project as I had hoped . I do like the silly thing though--it'll make a cute toy later.
Monday, November 9, 2009
Ha!
I recently discovered that my computer has a paint program on it (part of Appleworks, which I've only used for word processing before). It's an Apple program and although it has a different name it works just like the old Paint program on the Mac Classic that my family had when I was 12. I used to love that program--I'd spend hours playing with it and I was actually pretty good at drawing with a mouse. I'm completely out of practice now, and my laptop has no mouse so I drew the ideas here with my trackpad--not easy! It looks like I did it with my right hand if it had been drawn on paper (I'm a southpaw). But it was a trip down memory lane and kind of fun so I'll put it up anyway.....
Brain Parasites!
LEDs and Solder
Right--so here's last week's project, uploaded a tad late as I feel as though I've been living in my car or at work for the last five days. Blah.
Wednesday, October 28, 2009
Fake Blog
October 26th, 2022
Howdy Readers,
So today’s the day. After weeks of media hype we’ve finally reached the 20th anniversary of the strange plague that the pundits at the time dubbed “the people who grinned themselves to death”. For those of you who have been living under a rock lately (or who are just too young to remember) I’ll provide a quick recap:
On October 23rd 2012 two local hopitals here in San Jose reported one case each brought in through the E.R. of a strange sort of catatonia. The victims were largely nonresponsive, they would not speak, showed no signs of understanding when spoken to, and would only change position when physically moved, and most disturbingly, their faces were frozen in huge, happy grins. Doctors at each hospital were stumped, but not yet alarmed, as there was no reason to believe they were looking at anything than an isolated case of mental breakdown of some sort. The following day brought no new cases and nothing more was thought about it until the morning of the 25th when 14 more cases were brought into ERs around the city by frightened family members and the medical professionals began to realize that they were looking a new sort of epidemic. The number a victims rose steadily as the day progressed, maxing out emergency services capability to care for them. The CDC was called in to help contain the situation, although by this time reports were coming in of similar occurances in other places around the country. The true horror of the situation however didn’t hit until twenty years ago today, when San Jose awoke to discover that 40% of its population had become what would soon be known as “grinners”. The unaffected few could wander the streets passing crowds of people who had just stopped going about their business whereever they happened to be and were just standing there grinnning manically at nothing. They were completely nonresponsive, they could be posed like dolls, they were breathing, their hearts were pumping, but nothing else was happening. They would not eat or drink unless fed by I.V. in the overloaded hospitals and it wasn’t long before people began to die.
At the time no one knew what was going on--it was sudden and terrifiying and a complete mystery. It would be five weeks before doctors and scientists were able to discover the cause anf the cure, and when the knowledge was given to the public the riots began. The grinners had been infected with happy bugs--the cyborg product of a secret military project meant to be used to incapacitate enemy soldiers and populations for easier conquest. The tiny little bugs were partially mechanical--tiny nanorobots married to living insect tissue in the lab. The insects, controlled by HI-MEMS technolgy, outwardly appear no diffent than your average gadfly but when they bite they leave the host infected with microscopic cyborg parasites that make their way to the victims brain, attaching themselves to the the hypothalamus where they release their chemical load directly into the pleasure center of the brain, leaving the victim tractible and helpless. Learning that it was our own goverment that had, albiet accidentally, set this horror on its citizens was the last straw and the violence that followed was almost as devatating to the population as the infestation itself.
Nearly everyone lost people they loved in that month twenty years ago, and nobody who lived through the experience can ever look at a grinning face in quite the same way.
There are programs and memorials throughout the nation tonight, and I’m planning to attend the vigil being held at City Hall to remember the dead.
The End.
That's how it stands at the moment--I may well feel compelled to fuss with it some more as the project moves along as I've never been very good at leaving well enough alone....
--The Wombat
Monday, October 26, 2009
Still more research....
Oops!
Wee Research
Wednesday, October 21, 2009
Next!
This first bit is the research and early development part of the deal. I want to go back to my early interests in the class and see if I can't work out a nifty way to tie nanotechnology into this. I'm initially thinking microscopic critters that can invade a body, but I need to go do the actual research to help me nail it down a bit.
I'll back soon(ish) with more!
--The Wombat
Tuesday, October 20, 2009
Final Product
Wednesday, October 14, 2009
Actual Editing
Sunday, October 11, 2009
Editing Video Woes
I had started to watch the lynda.com videos for imovie, but then I realized that they were for imovie'06 and the computers in the lab have imovie'09 on them and they don't look at all the same, so videos telling me where to find things in one seem pretty useless for the other. It looks like our class lynda.com membership only lets us watch the particular videos listed for our course so I couldn't get any of the '09 tutorials to play. But Apple's website has a handful of online tutorials--just getting the general idea sort of things, which is just the right speed for me. I also just poked around on Google for any other tutorials and checked those out. This one wasn't bad. There are heaps of them on youtube, most of which seem to be made by wee little boys--it kinda cute. I liked this one and this one. I think I remeber what I watched, and I'll find out tomorrow in class (I've discovered that my computer won't accept any relatively recent version of imovie--its video card is too old? The message that popped up when I tried to install it from my ilife CD said something to that extent).
--The Wombat
Wednesday, October 7, 2009
Filming!
Must remember to blog.
Wednesday, September 30, 2009
Final Storyboard 1
Wednesday, September 23, 2009
More Video Research
Storyboarding: The (Very) Rough Drafts
Wednesday, September 16, 2009
Video Brainstorming
http://news.bbc.co.uk/2/hi/science/nature/7288426.stm
http://news.bbc.co.uk/2/hi/science/nature/3920685.stm
And a really long link to a google book that I'll shorten by doing this.
Next up on my list is robots/androids--human looking and acting machines. Japan has been doing a lot of work in this field with some amazing results. I think it would make a good video because people can be used as our props and there is a whole lot to explore--benefits, dangers, ethics, etc.
Here are my robot links:
http://www.foxnews.com/story/0,2933,279383,00.html
http://www.breitbart.com/article.php?id=CNG.bbd53bd17a5713678ea8bea533d92910.1bc1&show_article=1
http://www.usatoday.com/tech/news/robotics/2008-03-01-robots_N.htm
http://paro.jp/english/index.html
http://www.youtube.com/watch?v=SE2VCwYDjx0
http://www.youtube.com/watch?v=CyIHzCsbA_w
Lastly, I love the idea of the everyday stuff that we surround ourselves with getting a little bit more complicated and developing personalities of their own. I mean who doesn't argue with their computer, yell at their microwave, curse at their VCR, etc.? Now what if they talked back? Wouln't that be fun to watch?
I had been thinking it would be fun to do a scene in which a toaster was arguing with its human--turns out it has already been done (and in a Red Dwarf episode I've somehow never seen too!). But this is exactly the sort of thing I was thinking about:
http://www.youtube.com/watch?v=RZslRQvv5zM
http://www.the4cs.com/~corin/cse477/toaster/FAQ.shtml
Tuesday, September 8, 2009
It begins....
Welcome to the witterings of a wee wombat. As wombats lack opposable thumbs and have difficulty typing, we are not traditionally associated with blogging. However, this particular wombat wants an art degree and therefore must do its best to muddle through a Digital Media Art class. Said class requires said blog and here we are......
The blog itself is actually the second class project, to be added to throughout the term. The first entry is meant to display the first class project--a bit of internet research meant to expose our general interests to our instructor. It was aptly enough entitled Expose Yourself (yes, it’s funny--now pull your mind out of the gutter and keep reading).
Part one of the project asked that we select our favorite Media Art project from the following list and give a brief explanation of what we liked about it:
https://wiki.brown.edu/confluence/display/marktribe/new+media+art
I was most drawn to a project entitled Pedestrian by artists Paul Kaiser and Shelley Eshkar in which a tiny black and white urban world with tiny people is projected down onto the floor of a gallery, scurrying about their business amongst the feet of the viewers. The still image provided strongly resembled the works of any of several famous photographers and the write-up states that this was intentional. The movements of the animated figures was carefully researched using models in special motion suits reminiscent of Marey’s and Muybridge’s motion studies in the late 1800’s. It’s just a charming idea--a tiny little animated city swarming about your feet, looking like Modernist photographs and moving as realistically as possible. However, I do wonder what happens if they are stepped upon....
https://wiki.brown.edu/confluence/display/MarkTribe/Paul+Kaiser+and+Shelley+Eshkar
Part two of the project called for three things:
a) A news article reflecting a concern that we have about today’s social environment:
http://www.cnn.com/2009/HEALTH/08/31/online.internet.therapy.cbt/index.html
I chose this CNN feature about online psychotherapy on the basis that it instantly provoked me to a strong negative reaction. I do not care for the idea of online health care--especially for mental health. Isn’t the whole point of therapy that one talks to somebody about their issues? Our society seems to have this need to put everything online--banks, retail stores, public services, customer service, school, anything and everything. It strikes me as dehumanizing somehow.....or at the very least horribly impersonal.
b) A You Tube video that we found to be shocking or fascinating:
http://www.youtube.com/watch?v=glUnzzoFUxg
Watching this creepy Japanese robot crawl across the floor was definitely fascinating, in a morbid sort of way. Throw in the artist in the nurse’s outfit, the maintenance hatch/butt, and the confused little Australian boys and we’ve got a winner....what a great piece of performance art.
c) A piece of technology being developed for the future that caught our eye:
http://uwnews.org/article.asp?Search=parviz&articleid=39094
These little contact lenses look just like something out of any number of my favorite science fiction movies, tv shows, and books. The idea of granting humans super-human vision through the use of technology (and tiny, unobtrusive technology at that) is highly appealing. I like it when I see fictional devices becoming reality--now if only they could start perfecting the holodeck....
Overall, my selections exposed an interest in “People, illusion, online life, scale, mechanised people, future super human components” to my teacher. We'll see where these interests take me over the course of the semester.
--The Wombat